Fig. 2.
Densitometric analysis of pressure (shaded bars) effects on (A) Akt and (B) FAK phosphorylation in HT-1080 cells vs. ambient pressure (open bars), with typical blots from one of nine similar studies. Increasing ambient pressure by 15 mm Hg (DMSO-closed bar) stimulated Akt and FAK phosphorylation vs. ambient pressure controls (DMSO-open bar). Akt IV inhibitor or Y15 (FAK inhibitor) prevented pressure-induced Akt and FAK phosphorylation vs. cells under ambient pressure. *p<0.05 vs. DMSO ambient pressure, #p<0.05 vs. DMSO ambient pressure, NS – not significant.