Table 2.
Proportion of Subjects Recovering from Successive Prospectively Observed Episodes of Bipolar I Major Depressiona
| Time from Onset of Mood Episodeb | |||||||
|---|---|---|---|---|---|---|---|
| Mood Episode Number | Number of Subjects at Start of Mood Episode | 1 month | 3 months | 6 months | 1 year | 2 years | 5 years |
| 1 | 130 | 0.130 (0.045–0.345) | 0.460 (0.287–0.674) | 0.670 (0.486–0.842) | 0.840 (0.668–0.952) | 0.930 (0.784–0.990) | c |
| 2 | 80 | 0.120 (0.028–0.433) | 0.480 (0.265–0.750) | 0.720 (0.485–0.913) | 0.880 (0.664–0.984) | c | c |
| 3 | 52 | 0.120 (0.021–0.534) | 0.370 (0.149–0.733) | 0.710 (0.425–0.937) | 0.730 (0.439–0.949) | c | c |
a
Recovery from an episode of major depression was defined according to Research Diagnostic Criteria (Spitzer et al., 1978), which require at least eight consecutive weeks with either no symptoms or only one or two symptoms at a mild level of severity, and no impairment of functioning.
b
Proportions derived from Kaplan-Meier product-limit estimates (95% confidence interval).
c
Estimate was not calculated because of limited number of subjects at risk for recovery.