Table 2.
Selected heparin-binding proteins
| Heparin-binding protein | Biological roles | |||
|---|---|---|---|---|
| Proteases | AT | Anticoagulation and antithrombosis | ||
| HCF II | Anticoagulation and antithrombosis | |||
| Growth factors and cytokines | FGF-1 | Cell proliferation, differentiation, morphogenesis and angiogenesis | ||
| FGF-2 | Same as FGF-1 | |||
| VEGF | Cell growth, morphogenesis and development | |||
| HGF | Haepatocyte regeneration, morphogenesis, cell motility, tumourigenesis and metastasis | |||
| PF-4 | Inflammation and wound healing | |||
| IL-8 | Pro-inflammatory cytokine | |||
| γ-interferon | Dimerization and modulation of proteolytic processing | |||
| Enzymes | ApoE | Lipid transport, Alzheimer’s disease risk factor | ||
| Annexin V | Anticoagulant activity | |||
| Heparanase | Inflammation and metastasis | |||
| Pathogen proteins | HIV-1 gp120 | Viral entry | ||
| Tat | Transactivating factor, primes cells for HIV infection | |||
| HSV glycoproteinB and glycoproteinC | HSV attachment to the host cell | |||
| Adhesion proteins | Vitronectin | Cell adhesion and migration | ||
| Fibronectin | Cell adhesion and traction | |||
| Selectins | Adhesion, inflammation and metastasis | |||
| Integrins | Cell adhesion and signalling | |||