Fig 1.

Formation and resolution of DNA damage in human nasal epithelia from patients with seasonal allergic rhinitis receiving a single treatment of rhinophototherapy (RPT). Sample nasal epithelial tissue was collected from RPT patients that had received no RPT (-UV), immediately after the RPT treatment (T₀) and at 24 (T₂₄), 48 (T₄₈) and 72 (T₇₂) hrs after exposure. Cyclobutane dimers (grey bars) and (6–4) photoproducts (black bars) were determined using radioimmunoassay. Standard deviations were calculated from 4 data points from the RIAs of DNA extracted from tissue from various patients at different time points; including 30 patients prior to treatment, 30 immediately after treatment (T₀) and 10 patients at T₂₄, T₄₈ and T₇₂. Of the 30 original patients, the same patients were not necessarily available for tissue collection at all of the various time points.