Fig 5.

Nucleotide excision repair kinetics in 3D reconstructed normal human nasal epithelial and epidermal tissues. CPD and (6–4)PD repair are shown in EpiDerm (•–•) and EpiAirway (○–○) artificial tissues. The upper panels show the frequencies of CPDs (A) and (6–4)PDs (B) at increasing times post-irradiation as lesions per megabase DNA. Directly below each panel the frequencies have been normalized to the amount of damage measured at T₀ and are expressed as the percentage of CPDs (C) and (6–4)PDs (D) remaining at increasing times post-irradiation with a single sublethal dose of UVB. Exponential decay curves for each data set are shown. Standard errors of the mean were calculated from standard deviations using a total of 8 data points from duplicate tissues.