Table 2.
The effect of combination therapy with E10A plus docetaxel on inhibition of growth and metastasis of orthotopic prostate cancer in nude mice
| Treatment group | n | Tumour weight (mg) | LN metastasis |
|---|---|---|---|
| Untreated | 6 | 446 ± 107 | 6/6 |
| Ad-LacZ | 8 | 427 ± 138 | 7/8 |
| Doc | 6 | 213 ± 54a | 3/6 |
| Ad-LacZ+Doc | 8 | 194 ± 60 a | 5/8 |
| E10A | 8 | 234 ± 59 | 4/8 |
| E10A+Doc | 8 | 104 ± 33 b,c | 1/8b |
a
P < 0.05, compared with untreated and Ad-LacZ control.
b
P≤ 0.01 compared with untreated and Ad-LacZ control.
c
P < 0.05, compared with single agent and docetaxel plus Ad-LacZ.