Fig 4.

The effect of SC-560, a specific cyclooxgenase-1 inhibitor, and NS-398, a specific cyclooxygenase-2 inhibitor, on the H₂O₂-induced effects on pacemaker currents of ICC from the murine intestine. (A) Pacemaker currents exposed to 1 mM H₂O₂ after pretreating cells with 10 μM SC-560 at a holding potential of −70 mV. (B) The effect of 1 mM H₂O₂ on pacemaker currents after pretreating cells with 10 μM NS-398. (C, D and E) The inhibitory response to SC-560 or NS-398 on the H₂O₂-induced action on pacemaker currents. The bars represent mean ± S.E. values (n= 7). Asterisks indicate significantly different from H₂O₂ alone (P < 0.05).