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. 2008 Jul 10;14(1-2):257–266. doi: 10.1111/j.1582-4934.2008.00403.x

Fig 6.

Fig 6

The effect of PD98059, SB203580 and the JNK inhibitor on the H2O2-induced effects on pacemaker currents of ICC from the murine intestine. (A) The effect of 1 mM H2O2 on pacemaker currents after pretreating cells with 10 μM PD98059, a p44/42 MAPK inhibitor, for 15 min. (B) The effect of 1 mM H2O2 on pacemaker currents after pretreating cells with 10 μM SB203580, a p38 MAPK inhibitor, for 15 min. (C) The effect of 1 mM H2O2 on pacemaker currents after pretreating cells with 10 μM JNK inhibitor, c-jun NH2-terminal kinase inhibitor, for 15 min. (D) The effect of 1 μM PGE2 on pacemaker currents after pretreating cells with 10 μM PD98059 for 15 min. (E, F, and G) The inhibitory response to PD98059 on the H2O2-induced action on pacemaker currents. The bars represent mean ± S.E. values (n= 6/group). Asterisks indicate significantly different from H2O2 alone (P < 0.05), and the dotted lines indicate zero current levels. PD98059, PD; SB203580, SB; JNK inhibitor, JNK.