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. 2013 Nov;19(11):1721–1730. doi: 10.3201/eid1911.121356

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Number of reported cases of Tropheryma whipplei endocarditis per 1 million inhabitants in each area of France over 10 years. Data from this series and the literature (22–24) were included. Among the metropolitan areas in France, the incidence of T. whipplei endocarditis is significantly more frequent in the Rhône-Alpes area than in 11 others areas (Alsace, Aquitaine, Basse-Normandie, Bourgogne, Centre, Champagne-Ardenne, Haute-Normandie, Ile de France, Languedoc-Roussillon, Midi-Pyrénées, and Nord Pas-de-Calais; p = 0.04, p = 0.004, p = 0.048, p = 0.04, p = 0.01, p = 0.04, p = 0.02, p<0.001, p = 0.04, p = 0.007, p = 0.006, respectively). The incidence rate is also significantly more frequent in the Pays de la Loire area than in 6 other areas (Aquitaine, Bretagne, Centre, Ile-de France, Lorraine, Midi-Pyrénées, Nord Pas de Calais; p = 0.04, p = 0.04, p = 0.04, p = 0.003, p = 0.03, p = 0.02, respectively).