Table 1. Details of prion sources for ovine inocula*.
| Source code | Brain region | Prion agent | Ovine PrP genotype‡ |
|
Transmission data† |
|
|---|---|---|---|---|---|---|
| Attack rate (incubation period) | Reference | |||||
| AHVLA/SE 1919/0077 | Cerebral cortex | Classical scrapie | VRQ/VRQ | tg338 mice§; 16/16 (64 ± 2 d) | (21); code SE 1848/0005 | |
| AHVLA/SE 1919/0080 | Cerebral cortex | Classical scrapie | ARQ/ARQ | tg338 mice§ 12/13 (155 ± 4 d) | (21); code SE 1848/0008 | |
| FLI 1/06 | Caudal medulla | Classical scrapie | ARQ/ARQ | ND | NA | |
| FLI 83/04 | Caudal medulla | Classical scrapie | ARQ/ARQ | ND | NA | |
| FLI 107/04 | Caudal medulla | Classical scrapie | ARQ/ARQ | ND | NA | |
| AHVLA/SE 1850/0001 | Caudal medulla | Atypical scrapie | AHQ/AHQ | tg338 mice§; 19/20 (210 ± 3 d) | (22); code 1 | |
| AHVLA/SE 1850/0009 | Caudal medulla | Aypical scrapie | ARR/ARR | tg338 mice§; 19/19 (231 ± 6 d) | (22); code 9 | |
| FLI S7/06 | Caudal medulla | Atypical scrapie | AHQ/ARQ | ND | NA | |
| FLI 14/06 | Caudal medulla | Atypical scrapie | ARR/ARR | ND | NA | |
| FLI 26/06 | Caudal medulla | Atypical scrapie | AHQ/ARQ | ND | NA | |
| AHVLA/SE 1929/0877 | Caudal medulla | Ovine BSE | ARQ/ARQ | RIII mice; 16/19 (422 ± 19 d)¶ | Unpub. | |
| AHVLA/SE1945/0032 | Rostral medulla | 2nd Passage ovine BSE | ARQ/ARQ | RIII mice; 18/20 (356 ± 9 d)¶ | Unpub. | |
*PrP, prion protein; AHVLA, Animal Health and Veterinary Laboratories Agency; ND, not done; NA, not applicable; FLI, Friedrich-Loeffler-Institut; BSE, bovine spongiform encephalopathy; Unpub., unpublished. †Reports attack rate (the no. of infected mice as a proportion of the no. of inoculated mice) and mean incubation period in days ± SEM or SD and the reference in which the data were first published with original inocula code. ‡Ovine PrP codon 136,154,171 genotype. §Transgenic for the ovine Prnp VRQ allele on a mouse Prnp0/0 background. Overexpression 8- to 10-fold of normal ovine brain. ¶Mean incubation period in days ± SEM.