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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Dec;1828(12):10.1016/j.bbamem.2013.05.005. doi: 10.1016/j.bbamem.2013.05.005

Figure 2.

Figure 2

Viral infection-induced RIP of CREB3L1

Viral infection-induced production of ceramide and/or ER stress caused by massive synthesis of virus-encoded membrane proteins may stimulate translocation of CREB3L1 precursor from the ER to Golgi, where the protein is sequentially cleaved by S1P and S2P. This cleavage releases the NH2-terminal domain of CREB3L1 from membranes, allowing it to enter the nucleus where it activates genes encoding cell cycle inhibitors to block proliferation of the virus-infected cells.