Table 2. Polymorphism in one-carbon metabolism genes and clear cell renal cell carcinoma risk.
| Position | MAF | Cases, n (%) | Controls, n (%) | P-valuea | Adjusted OR (95% CI)b | P trenda | HWE | |
| CBS | ||||||||
| rs1788484 | promoter | 0.222 | ||||||
| CC | 535(62.3) | 543(54.0) | <0.001 | Ref. | 0.022 | <0.001 | ||
| CT | 275(32.0) | 425(42.3) | 0.62(0.51–0.76) | |||||
| TT | 49(5.7) | 37(3.7) | 1.27(0.79–2.20) | |||||
| TT vs. CC+CT | 0.038 | 1.53(0.97–2.41) | ||||||
| CT+TT vs. CC | <0.001 | 0.67(0.55–0.82) | ||||||
| rs706209 | 3′UTR | 0.329 | ||||||
| TT | 401(46.7) | 396(39.4) | 0.006 | Ref. | 0.007 | 0.379 | ||
| TC | 358(41.7) | 480(47.8) | 0.76(0.62–0.92) | |||||
| CC | 100(11.6) | 129(12.8) | 0.74(0.55–1.01) | |||||
| CC vs. TT+TC | 0.434 | 0.87(0.65–1.16) | ||||||
| TC+CC vs. TT | 0.002 | 0.76(0.62–0.91) | ||||||
| MTRR | ||||||||
| rs2966952 | promoter | 0.333 | ||||||
| CC | 371(43.2) | 463(46.1) | 0.120 | Ref. | 0.064 | 0.978 | ||
| CT | 374(43.5) | 438(43.6) | 1.07(0.88–1.31) | |||||
| TT | 114(13.3) | 104(10.4) | 1.40(1.03–1.91) | |||||
| TT vs. CC+CT | 0.050 | 1.34(1.00–1.80) | ||||||
| CT+TT vs. CC | 0.213 | 1.13(0.93–1.36) | ||||||
| rs9332 | 3′UTR | 0.188 | ||||||
| CC | 651(75.8) | 708(70.5) | 0.027 | Ref. | 0.007 | 0.434 | ||
| CT | 196(22.8) | 275(27.4) | 0.75(0.60–0.93) | |||||
| TT | 12(1.4) | 22(2.2) | 0.65(0.31–1.33) | |||||
| TT vs. CC+CT | 0.203 | 0.70(0.34–1.43) | ||||||
| CT+TT vs. CC | 0.010 | 0.74(0.60–0.92) | ||||||
| rs10520873 | 3′UTR | 0.311 | ||||||
| AA | 593(69.0) | 648(64.5) | 0.063 | Ref. | 0.098 | 0.032 | ||
| AG | 240(27.9) | 331(32.9) | 0.79(0.64–0.97) | |||||
| GG | 26(3.0) | 26(2.6) | 1.15(0.65–2.04) | |||||
| GG vs. AA+AG | 0.566 | 1.24(0.70–2.19) | ||||||
| AG+GG vs. AA | 0.038 | 0.82(0.67–1.00) | ||||||
| TYMS | ||||||||
| rs2853741 | promoter | 0.411 | ||||||
| TT | 264(30.7) | 356(35.4) | 0.096 | Ref. | 0.046 | 0.982 | ||
| TC | 439(51.1) | 484(48.2) | 1.25(1.01–1.54) | |||||
| CC | 156(18.2) | 165(16.4) | 1.24(0.93–1.64) | |||||
| CC vs. TT+TC | 0.321 | 1.08(0.84–1.39) | ||||||
| TC+CC vs. TT | 0.032 | 1.25(1.02–1.53) | ||||||
| rs699517 | 3′UTR | 0.3 | ||||||
| TT | 420(48.9) | 537(53.4) | 0.108 | Ref. | ||||
| TC | 358(41.7) | 391(38.9) | 1.25(1.02–1.52) | 0.035 | 0.619 | |||
| CC | 81(9.4) | 77(7.7) | 1.26(0.89–1.78) | |||||
| CC vs. TT+TC | 0.172 | 1.25(1.03–1.51) | ||||||
| TC+CC vs. TT | 0.051 | 1.15(0.82–1.61) |
a
Two-sided χ2-test for either genotype distributions or trend between the cases and controls.
b
genotype-specific ORs were adjusted for age, gender, BMI, smoking status, drinking status, diabetes and hypertension in logistic regression model.