Table 4. Association between the combined genotypes of rs706209 and rs9332 polymorphisms and clinicopathologic characteristics of clear cell renal cell carcinoma.
| Variables | Risk allele | P-valuea | Adjusted OR (95% CI)b | |||
| 0 | 1–4 | |||||
| n | % | n | % | |||
| Control (n = 1005) | 286(28.5) | 719(71.5) | Ref. | |||
| Case (n = 859) | ||||||
| Clinical stage | ||||||
| Localized (I+II) | 265(35.5) | 482 (64.5) | 0.002 | 1.37 (1.11–1.69) | ||
| Advanced (III+IV) | 39 (34.8) | 73 (65.2) | 0.160 | 1.30 (0.86–1.98) | ||
| Grade | ||||||
| Well- differentiated (I+II) | 234 (36.2) | 412 (63.8) | <0.001 | 1.42 (1.14–1.76) | ||
| Moderately and Poorly differentiated(III+IV) | 70 (32.9) | 143 (67.1) | 0.199 | 1.21 (0.87–1.68) | ||
a
Two-sided χ2 test for the distributions of genotypes.
b
Adjusted for age, gender, BMI, smoking status, drinking status, hypertension and diabetes in logistic regression model.