Table 1.
Test Performance Assumptions for Various Screening Strategies (at Selected Thresholds) for Identifying Children With Diabetes Mellitus and Dysglycemia for the Base-Case Analysis and Sensitivity Analyses
| Screening Strategy and Cutoff Value | Sensitivity, % | Specificity, % |
|---|---|---|
| Base-Case Analysis | ||
| Diabetes mellitus | ||
| 2-h OGTT (200 mg/dL) | 100 | 100 |
| HbAlc | ||
| 5.5% | 33 | 56 |
| 5.7% | 33 | 71 |
| 6.5% | 33 | 96 |
| Dysglycemia (prediabetes and diabetes) | ||
| 2-h OGTT (140 mg/dL) | 100 | 100 |
| Random glucose test | ||
| 100 mg/dL | 55 | 67 |
| 110 mg/dL | 30 | 88 |
| HbAlc | ||
| 5.5% | 45 | 57 |
| 5.7% | 32 | 74 |
| 6.5% | 7 | 98 |
| 1-h Glucose challenge test | ||
| 110 mg/dL | 63 | 63 |
| 120 mg/dL | 44 | 81 |
|
| ||
| Sensitivity Analyses | ||
| Diabetes mellitus | ||
| HbAlc | ||
| 5.7% | 71 | 79 |
| 6.5% | 32 | 99 |
| Dysglycemia (prediabetes and diabetes) | ||
| HbAlc | ||
| 5.7% | 34 | 83 |
| 6.5% | 4 | 100 |
Abbreviations: HbA1c hemoglobin A1c; OGTT, oral glucose tolerance test.