Figure 8.

Sensory and motor deficits are exacerbated and sustained in scLRP1^−/− mice following PNL. A, Mechanical allodynia was measured by non-noxious probing of the hindpaw using von Frey filaments before and after PNL. Data are expressed as means ± SEM (N = 10–12/cohort). Differences in treatment groups were compared by Scheffe's post hoc test (*p < 0.05 comparing genotypes at baseline; *p < 0.05 compared with sham-operated mice in the same genotype; **p < 0.01 comparing scLRP1^−/− mice with all groups). B, Rotarod testing of scLRP1^+/+ and scLRP1^−/− mice before and after PNL. The time until failure is plotted (*p < 0.05 compared with sham-operated mice, n = 12/cohort).