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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: J Mol Cell Cardiol. 2013 Sep 10;64:10.1016/j.yjmcc.2013.09.001. doi: 10.1016/j.yjmcc.2013.09.001

Figure 7.

Figure 7

Panel A: Representative IKs currents from 2 week-old neonate ventricular myocyte. E-4031 (5 μM) was present to eliminate IKr. IKs tail currents were not observed at any potential studied. Panel B: Protocol repeated in the presence of 100 nM isoproterenol. ICa was greatly augmented, although IKs was still absent. Panel C: Representative IKs currents from an adult ventricular myocyte. E-4031 (5 μM) was present to eliminate IKr. IKs tail currents were readily observed in adults using the same protocol. Panel D: IKs was augmented in the presence of 100 nM isoproterenol. Panel E: Ion channel gene expression in adult ventricular tissue (relative to neonatal). Data are presented as box plots with the mean together with upper and lower confidence levels (95%). KCNQ1, KCND3 and KCNIP2 are higher in adult compared with neonate, while KCNH2 is unchanged. KCNJ2 is less in the adult ventricle compared with neonate.