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Summary of inhibition parameters for the four major inhibitory interactions, including the mechanism of inhibition, Ki, α, and IC50s
| Enzyme | Inhibitor | Mechanism | Ki (μM) | α | IC50 (μM) |
|---|---|---|---|---|---|
| DszA | HBP | Not determined | NAa | NA | 60 ± 5 |
| DszB | HBP | Not determined | NA | NA | 110 ± 10 |
| DszC | HBPS | Noncompetitive | 13.5 | 0.13 | 15 ± 2 |
| DszC | HBP | Noncompetitive | 40 | 0.4 | 50 ± 5 |
NA, not applicable.
