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Structural analysis of the predicted effect of the 4′-ethynyl group of EFdA (yellow sticks) on interactions with the binding pocket of ADA (gray surface). When EFdA binds in a manner similar to that of other substrates, the 4′-ethynyl group may clash with the sulfur and ε-carbon atoms of Met155 in ADA. The figure was made using the PyMOL molecular graphics software package (http://www.pymol.org/).
