Table 1.
Summary of pseudorotational analysis of the sugar ring of deoxyadenosine and thymidine analogs
| Compound (no.) | PN (°) | PS (°) | ϕm(N) (°) | ϕm(S) (°) | % North | RMS error (Hz)a |
|---|---|---|---|---|---|---|
| Deoxyadenosine analogs | ||||||
| dA (1)b | 18.7 | 169.1 | 39.0c | 31.1 | 23 | 0.03 |
| FdA (2) | 3.4 | 169.1 | 38.7 | 29.2 | 24 | 0.01 |
| EdA (3) | 37.3 | 152.1 | 39.0c | 39.0c | 64 | 0.40 |
| EdDAP (4) | 39.7 | 152.1 | 39.0c | 39.0c | 63 | 0.49 |
| EFdA (5)b | 38.7 | 146.5 | 39.0c | 39.0c | 75 | 0.20 |
| ECldA (6) | 38.4 | 148.0 | 39.0c | 39.0c | 73 | 0.21 |
| CNdA (7) | 47.8 | 152.8 | 38.0c | 38.0c | 61 | 0.12 |
| CNdDAP (8) | 45.0 | 154.0c | 37.2 | 38.0c | 56 | 0.12 |
| CNFdA (9) | 41.6 | 154.2 | 38.0c | 38.0c | 59 | 0.23 |
| Thymidine analogs | ||||||
| MedT (13) | 24.3 | 132.5 | 38.0c | 31.5 | 43 | 0.05 |
| EtdT (14) | 23.3 | 150.3 | 38.0c | 30.2 | 39 | 0.18 |
a
Root mean square deviation between experimental and calculated coupling constants.
b
Values previously reported (36).
c
Value fixed during calculations.