Table 1.
In vitro susceptibilities and in vivo fitness of selected A. fumigatus isolates
| A. fumigatus isolate | MIC (mg/liter) |
In vivo fitnessa | Comment | |
|---|---|---|---|---|
| Isavuconazole (BAL4815) | Posaconazole | |||
| AF41 | 0.25 | 0.25 | 1.85 | Wild type |
| AF293 | 1 | 0.5 | 2.20 | Wild type |
| DPL EC S 1 | 0.5 | 0.25 | 2.63 | Wild type |
| EMFR S678P | 0.25 | 0.25 | 2.42 | Fks1 S678P (echinocandin MIC, >16 mg/liter) |
| F11628 | 8 | 8 | 2.80 | cyp51 G138C |
| F14403 | 0.125 | 8 | 1.92 | cyp51 G54R |
| F16216 | 8 | 2 | 2.55 | cyp51 L98H + TR |
| AF72 | 2 | 2 | 2.32 | cyp51 G54E |
| F14532 | 1 | 1 | 2.52 | cyp51 M220T |
| F13737 | 4 | 2 | 2.45 | cyp51 G434C |
a
In vivo fitness is defined as the growth, measured in log10 CE/ml of lung homogenate, of the isolate in untreated animals until the time of death or sacrifice.