Table 2.

In vivo PD efficacy of isavuconazole in an immunocompromised murine pulmonary aspergillosis model^a

Isolate or parameter	MIC (mg/liter)	Static dose (mg/kg/12 h)	Static-dose 24-h AUC (mg · h/liter	Static-dose 24-h AUC/MIC ratio	Static-dose 24-h free-drug AUC/MIC ratio	1-Log killing dose (mg/kg/12 h)	1-Log killing 24-h AUC (mg · h/liter)	1-Log killing 24-h AUC/MIC ratio	1-Log killing 24-h free-drug AUC/MIC ratio
AF41	0.25	360	278	1,111	11.1	421	311	1,242	12.4
AF293	1	617	415	415	4.15
DPL EC S 1	0.5	393	295	591	5.91	455	328	657	6.57
EMFR S678P	0.25	212	199	794	7.94	302	247	988	9.88
F11628	8
F14403	0.125	65.0	45.9	367	3.67	147	154	1,235	12.4
F16216	8
AF72	2
F14532	1	515	361	361	3.61
F13747	4
Median		376	287	503	5.03	362	279	1,111	11.1
SD		200	131	298	2.98	139	78.7	276	2.76

^aBlank cells represent strains for which the endpoint was not achieved.