Table 2.
Motavizumab and mota-YTE mean pharmacokinetic parameter values
| Dose and treatment | Mean value for the parametera |
|||||
|---|---|---|---|---|---|---|
| Cmax (μg/ml) | Clearance (ml/day) | Half-life (days) | Vol of distribution (liters) | AUClast (μg · day/ml) | AUCinf (μg · day/ml) | |
| 0.3 mg/kg | ||||||
| Mota-YTE | 8.8 (16.2) | 58.5 (7.8) | 69.5 (2.4) | 5.8 (2.7) | 300.4 (3.8) | 342.8 (7.8) |
| Motavizumab | 8.9 (24.1) | 203.2 (12.4) | 18.9 (28.3) | 5.3 (27.3) | 90.4 (14.6) | 99.5 (13.1) |
| 3 mg/kg | ||||||
| Mota-YTE | 82.8 (31.8) | 44.2 (19.6) | 100.4 (10.5) | 6.3 (17.3) | 4,193.3* (6.4) | 5,224.0* (4.2) |
| Motavizumab | 59.3 (39.1) | 322.8 (46.7) | 22.3 (33.5) | 8.5 (39.7) | 784.6 (58.9) | 850.5 (56.8) |
| 15 mg/kg | ||||||
| Mota-YTE | 324.1 (15.0) | 67.5 (18.7) | 84.3 (18.6) | 8.3 (11.5) | 15,328.7† (11.4) | 18,022.3† (13.6) |
| Motavizumab | 232.9 (4.3) | 325.6 (34.2) | 20.4 (52.2) | 9.5 (12.7) | 2,903.8 (19.0) | 3,262.1 (26.8) |
| 30 mg/kg | ||||||
| Mota-YTE | 938.1 (3.6) | 43.3 (3.8) | 73.2 (4.0) | 4.6 (1.1) | 44,159.4† (14.9) | 49,276.6† (13.7) |
| Motavizumab | 898.2 (13.9) | 164.9 (33.7) | 34.4 (25.8) | 5.2 (13.5) | 13,180.6 (31.3) | 13,303.3 (31.3) |
a
The coefficient of variation (percent) is given in parentheses. AUC, area under the curve; Cmax, maximum concentration, infinity. Significant difference is indicated as follows: *, P < 0.001 for mota-YTE compared with motavizumab; †, P < 0.01 for mota-YTE compared with motavizumab.