Table 2.

Efficacies of antibiotic monotherapies and of tigecycline combinations after 24 and 48 h of treatment vs results for untreated animals^a

Isolate	TIG vs no treatment		COL vs no treatment		GEN vs no treatment		MER vs no treatment		RIF vs no treatment		TIG + COL vs no treatment		TIG + GEN vs no treatment		TIG + MER vs no treatment		TIG + RIF vs no treatment
	Δlog	P valueb	Δlog	P value	Δlog	P value	Δlog	P value	Δlog	P value	Δlog	P value	Δlog	P value	Δlog	P value	Δlog	P value
24 h of treatment
K 1/4089	0.16	0.644	−0.001	0.990	−0.05	0.590	0.02	0.558	−2.41	0.002	−0.16	0.071	−1.87	0.003	−1.36	0.004	−4.81	<0.001
K 2/4179	−0.24	0.137	−0.11	0.068	−0.39	0.256	−0.24	0.137	−2.25	<0.001	−3.14	0.023	−4.42	0.007	−1.81	0.077	−3.87	0.007
K 3/3268	−2.51	0.032	0.85	0.002	−1.51	0.002	−0.15	0.182	−2.55	0.002	−2.75	0.109	−4.72	0.004	−1.38	0.004	−4.54	<0.001
K4/3712	−5.23	<0.001	0.41	0.414	−1.38	0.046	−0.60	0.080	−2.66	0.002	−3.45	0.001	−4.20	<0.001	−2.03	0.002	−5.84	<0.001
K5/2458	−2.98	0.003	−0.52	0.052	−1.02	<0.001	−1.33	0.003	−3.03	0.001	−3.80	0.003	−4.86	<0.001	−3.56	0.001	−5.17	<0.001
K6/3189	−5.48	<0.001	−1.11	0.015	−1.36	0.019	−1.12	0.003	−3.48	<0.001	−4.74	0.001	−5.86	<0.001	−4.87	<0.001	−5.71	<0.001
K7/2868	−2.62	0.006	−1.47	0.023	−0.88	0.112	−0.27	0.341	−0.98	0.143	−2.38	0.025	−3.09	<0.001	−2.68	<0.001	−3.45	0.008
K8/3342	−1.55	0.006	−0.44	0.184	−1.96	0.004	−0.84	0.112	−1.55	0.011	−1.04	0.001	−1.90	0.027	−1.27	0.038	−4.20	<0.001
E1/1098	−2.60	0.001	0.12	0.588	−1.52	0.029	−1.77	0.004	−2.44	0.004	−3.11	0.015	−2.52	0.005	−2.67	0.029	−3.10	<0.001
ATCC 25922	−2.37	0.003	−0.62	0.394	−0.77	0.305	−4.15	0.001	−1.63	0.004	−4.05	0.015	−5.04	<0.001	−6.05	<0.001	−4.81	<0.001
48 h of treatment
K 1/4089	0.26	−0.844	−0.10	0.224	−0.24	0.558	−0.67	0.053	−2.10	0.035	−0.18	0.275	−4.28	0.003	−0.11	0.105	−4.47	<0.001
K 2/4179	0.101	0.233	−0.79	0.262	−0.87	0.003	−0.15	0.195	−1.60	0.027	−3.13	0.018	−4.58	0.014	−0.98	0.08	−5.60	<0.001
K 3/3268	−3.70	<0.001	−0.76	0.182	−1.15	0.001	−0.58	0.337	−1.75	0.014	−1.90	0.169	−3.58	0.022	−3.38	<0.001	−3.76	0.001
K4/3712	−5.54	<0.001	−5.22	<0.001	−3.02	0.001	0.01	0.913	−2.27	0.014	−6.10	<0.001	−7.08	<0.001	−5.91	0.001	−7.11	<0.001
K5/2458	−5.67	0.002	−1.67	0.026	−1.90	0.004	−1.24	<0.001	−3.90	0.002	−5.89	0.001	−6.77	<0.001	−5.70	<0.001	−6.19	<0.001
K6/3189	−3.94	<0.001	−0.21	0.495	−2.90	0.028	−1.37	0.011	−3.76	0.002	−4.09	0.015	−5.65	<0.001	−2.70	<0.001	−6.49	<0.001
K7/2868	−2.96	0.010	−2.18	0.014	−2.72	0.036	−0.23	0.161	−2.78	0.003	−2.31	0.015	−4.62	<0.001	−1.44	0.025	−4.66	<0.001
K8/3342	−0.24	0.054	−0.91	0.266	−2.77	<0.001	−0.52	0.217	−3.22	0.002	−1.22	0.015	−2.51	0.003	−1.54	0.058	−3,98	0.002
E1/1098	−4.57	0.008	0.27	0.399	−1.86	0.027	−2.12	0.007	−4.55	<0.001	−0.68	0.457	−4.10	0.010	−3.95	0.001	−5.16	<0.001
ATCC 25922	−3.95	0.002	−0.99	0.029	−1.40	0.121	−3.85	<0.001	−2.80	0.024	−5.56	0.002	−6.27	<0.001	−6.23	<0.001	−6.00	<0.001

^aK, K. pneumoniae; E, E. coli; TIG, tigecycline; COL, colistin; GEN, gentamicin; MER, meropenem; RIF, rifampin.

^bA P value of <0.05 indicates significance and is shown in bold.