Table 4.

Comparison of the efficacies of tigecycline combinations vs monotherapies after 24 and 48 h of treatment^a

Isolate	TIG vs TIG + COL		TIG vs TIG + GEN		TIG vs TIG + MER		TIG vs TIG + RIF		COL vs TIG+COL		GEN vs TIG + GEN		MER vs TIG + MER		RIF vs TIG + RIF
	Δlog	P valueb	Δlog	P value	Δlog	P value	Δlog	P value	Δlog	P value	Δlog	P value	Δlog	P value	Δlog	P value
24 h of treatment
K 1/4089	0.27	0.534	1.98	0.048	1.48	0.038	2.83	0.002	0.63	0.036	1.79	0.004	1.35	<0.001	1.28	0.006
K 2/4179	2.97	0.026	4.16	0.010	1.57	0.094	1.86	0.044	2.80	0.008	4.22	0.006	1.57	0.094	0.62	0.315
K 3/3268	1.00	0.081	2.21	0.095	−1.13c	0.148	1.72	<0.001	3.87	0.013	3.21	0.001	1.14	0.001	1.98	0.001
K4/3712	0.05	0.918	0.80	0.074	−1.37c	0.002	0.62	0.125	5.46	0.001	−0.93c	0.054	0.47	0.135	2.77	0.002
K5/2458	0.83	0.307	1.88	0.027	0.58	0.364	2.19	0.011	3.28	0.008	3.83	0.001	2.23	0.009	2.14	0.001
K6/3189	−0.74c	0.108	0.38	0.136	−0.61c	0.014	0.22	0.065	3.63	0.001	4.50	0.001	3.75	0.001	2.22	<0.001
K7/2868	−0.24c	0.515	0.46	0.199	0.07	0.843	0.48	0.182	2.01	0.063	0.98	0.100	1.65	<0.001	0.44	0.502
K8/3342	−0.51c	0.186	0.35	0.614	−0.28c	0.597	2.38	0.008	1.69	0.003	1.57	0.061	1.27	0.024	2.02	0.002
E1/1098	0.52	0.090	0.17	0.559	0.56	0.390	0.18	0.398	3.25	0.005	2.80	<0.001	2.31	0.035	2.96	<0.001
ATCC 25922	1.68	0.155	2.67	0.006	3.68	0.010	2.43	0.005	3.43	0.027	4.28	0.006	1.90	0.037	3.17	<0.001
48 h of treatment
K 1/4089	−0.51c	0.561	2.17	0.134	−1.58c	0.230	2.55	0.008	1.02	0.322	6.65	0.001	−0.60c	0.062	2.17	0.033
K2/4179	3.07	0.004	4.88	0.001	1.15	0.004	5.46	<0.001	2.16	0.040	3.90	0.001	0.90	0.031	3.76	0.001
K 3/3268	−0.90c	0.429	−1.21c	0.848	−0.18c	0.349	0.80	0.016	1.60	0.282	1.84	0.074	9.91	0.015	2.89	0.008
K4/3712	0.97	0.110	1.28	0.153	0.24	0.611	1.56	0.001	0.42	0.053	3.16	0.001	5.04	0.002	3.95	0.003
K5/2458	0.22	0.787	1.10	0.155	0.03	0.964	0.52	0.435	4.23	0.009	4.87	0.001	4.45	0.001	2.29	0.008
K6/3189	0.15	0.871	1.71	0.001	−1.25c	0.001	2.55	0.001	3.87	0.014	2.76	0.038	1.32	0.012	2.73	0.003
K7/2868	−0.64c	0.342	1.67	0.031	−1.52c	0.003	3.88	<0.001	2.11	0.019	4.05	0.001	0.58	0.305	2.48	0.031
K8/3342	0.90	0.076	2.19	0.002	1.21	0.083	0.36	0.541	1.20	0.024	2.55	0.002	1.58	0.054	3.22	0.005
E1/1098	−3.72c	0.002	−0.29c	0.495	−0.43c	0.241	−0.28c	0.612	0.45	0.370	3.72	0.001	2.81	0.001	3.68	0.002
ATCC 25922	1.62	0.134	2.33	0.007	2.28	0.018	2.06	0.038	4.58	0.006	4.88	0.007	2.38	0.002	3.20	0.007

^aK, K. pneumoniae; E, E. coli; TIG, tigecycline; COL, colistin; GEN, gentamicin; MER, meropenem; RIF, rifampin.

^bA P value of <0.05 indicates significance and is shown in bold.

^cAntagonistic combination.