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. 2013 Dec;57(12):6028–6033. doi: 10.1128/AAC.00891-13

Table 5.

Comparison of the efficacies of tigecycline combinations after 24 and 48 h of treatmenta

Isolate TIG + COL vs TIG + GEN
 TIG + COL vs TIG + MER
 TIG + COL vs TIG + RIF
 TIG + GEN vs TIG + MER
 TIG + GEN vs TIG + RIF
 TIG + MER vs TIG + RIF
Δlog P valueb Δlog P value Δlog P value Δlog P value Δlog P value Δlog P value
24 h of treatment
    K 1/4089 1.71 0.003 1.20 0.003 3.47 0.005 −0.50 0.085 1.73 0.033 2.37 0.001
    K 2/4179 1.70 0.127 −1.19 0.202 −0.07 0.933 −2.88 0.004 −1.76 0.081 1.12 0.308
    K 3/3268 1.71 0.151 −1.72 0.089 1.52 0.159 −3.43 <0.001 −0.19 0.147 3.24 0.001
    K4/3712 0.75 0.049 −1.42 0.038 0.56 0.098 −2.17 0.003 −0.91 0.003 1.99 0.003
    K5/2458 1.05 0.159 −0.24 0.648 1.37 0.047 −1.23 0.002 0.315 0.168 1.61 0.003
    K6/3189 1.12 0.040 0.13 0.615 0.97 0.083 −0.99 0.004 −0.15 0.397 0.84 0.011
    K7/2868 0.70 0.245 0.30 0.580 1.69 0.032 −0.90 0.006 −1.17 0.114 1.55 0.026
    K8/3342 0.86 0.135 0.23 0.520 0.56 0.311 −0.63 0.092 1.00 0.226 0.52 0.229
    E1/1098 −0.35 0.280 0.04 0.942 0.74 0.215 0.39 0.303 −0.64 0.371 1.98 0.034
    ATCC 25922 0.99 0.230 2.00 0.023 0.76 0.278 1.01 0.032 −0.23 0.290 −1.25 0.027
48 h of treatment
    K 1/4089 2.68 0.013 −1.06 0.295 3.03 0.058 −3.82 0.002 0.38 0.378 4.20 <0.001
    K 2/4179 1.82 0.045 −1.70 0.078 2.40 0.003 −3.60 0.016 0.59 0.285 4.25 0.003
    K 3/3268 0.64 0.151 1.14 0.217 2.29 0.074 0.50 0.515 1.65 0.115 1.15 0.017
    K4/3712 0.17 0.588 −0.99 0.110 0.98 0.038 −1.16 0.188 −1.15 0.058 1.19 0.092
    K5/2458 0.88 0.067 −0.20 0.635 0.30 0.519 −1.08 0.005 −0.88 0.035 0.50 0.133
    K6/3189 1.57 0.174 −1.40 0.187 2.40 0.063 −2.96 <0.001 0.84 0.003 3.80 <0.001
    K7/2868 2.31 0.023 −0.87 0.166 1.98 0.041 −3.18 0.002 0.36 0.711 2.76 0.033
    K8/3342 1.29 0.068 0.31 0.694 0.96 0.133 −0.98 0.170 1.46 0.137 0.87 0.132
    E1/1098 3.42 0.003 3.28 0.005 1.27 0.208 −0.14 0.612 −0.79 0.165 2.79 0.009
    ATCC 25922 0.71 0.251 0.66 0.191 0.44 0.186 −0.05 0.802 −0.27 0.364 −0.23 0.313
a

K, K. pneumoniae; E, E. coli; TIG, tigecycline; COL, colistin; GEN, gentamicin; MER, meropenem; RIF, rifampin.

b

A P value of <0.05 indicates significance and is shown in bold.