Table 2.
Susceptibility to carbapenem antibiotics in carbapenemase-producing Enterobacteriaceae isolated in Spain (2012)
| Carbapenemase type (no. of isolates) | Carbapenem | MIC (μg/ml) |
%a |
||||
|---|---|---|---|---|---|---|---|
| Range | 50% | 90% | S | I | R | ||
| OXA-48 like (n = 163) | Ertapenem | 2–>4 | 4 | >4 | 0 | 0 | 100 |
| Imipenem | ≤1–>8 | 2 | >8 | 66.3 | 20.2 | 13.5 | |
| Meropenem | ≤1–>8 | 4 | >8 | 30 | 47.9 | 22.1 | |
| VIM-1 (n = 60) | Ertapenem | 1–>4 | 4 | >4 | 0 | 10 | 90 |
| Imipenem | ≤1–>8 | 4 | >8 | 15 | 55 | 30 | |
| Meropenem | ≤1–>8 | 8 | >8 | 18.3 | 40 | 41.7 | |
| IMP-like (n = 5) | Ertapenem | 4–>4 | >4 | >4 | 0 | 0 | 100 |
| Imipenem | ≤1–2 | 2 | 2 | 100 | 0 | 0 | |
| Meropenem | 2–>8 | 8 | >8 | 20 | 60 | 20 | |
| KPC-like (n = 8) | Ertapenem | >4–>4 | >4 | >4 | 0 | 0 | 100 |
| Imipenem | 4–>8 | 4 | >8 | 0 | 75 | 25 | |
| Meropenem | 2–>8 | 8 | >8 | 25 | 25 | 50 | |
a
S, susceptible isolates according to EUCAST breakpoints; I, intermediate isolates according to EUCAST breakpoints; R, resistant isolates according to EUCAST breakpoints.