Table 1.

In vitro activity of compound A, compound B, and novobiocin against the ATPase function of the E. coli DNA gyrase and topoisomerase IV enzymes

Compound	IC50 (μg/ml)a
	DNA gyrase	Topoisomerase IV
A	0.0039 ± 0.0017 (0.0077 ± 0.0034)	0.046 ± 0.030 (0.091 ± 0.060)
B	0.0033 ± 0.0021 (0.0064 ± 0.0041)	0.024 ± 0.012 (0.046 ± 0.023)
Novobiocin	0.045 ± 0.027 (0.073 ± 0.044)	0.18 ± 0.059 (0.29 ± 0.096)

^aData in parentheses are IC₅₀s in μM.