Table 4.
Summary of the results obtained from the allometric scaling model and linear BSA model as implemented with the pediatric data seta
| Parameter | Allometric scaling |
Linear BSA |
||
|---|---|---|---|---|
| Model estimate (bootstrap %RSE) | Bootstrap 95% CI | Model estimate (bootstrap %RSE) | Bootstrap 95% CI | |
| CL/F (liters/h) | 923 (9.41) | 765, 1,101 | 884 (9.40) | 732, 1,052 |
| V2/F (liters) | 1,130 (16.6) | 794, 1,538 | 884 (16.6) | 617, 1,208 |
| CLM/F (liters/h) | 65.1 (8.54) | 55.2, 77.5 | 62.3 (8.56) | 52.8, 74.3 |
| V3/F (liters/h) | 79.1 (12.1) | 61.6, 101 | 63.9 (12.0) | 49.6, 80.9 |
| ka (h−1) | 2.46 (20.7) | 1.92, 3.92 | 2.27 (19.8) | 1.78, 3.54 |
| Effect of gender on CL/F | 1.07 (12.0) | 0.826, 1.34 | 1.08 (11.9) | 0.829, 1.35 |
| Effect of gender on V2/F | 1.06 (22.9) | 0.738, 1.72 | 1.06 (23.3) | 0.745, 1.70 |
| Effect of gender on CLM/F | 1.05 (10.6) | 0.861, 1.29 | 1.05 (10.7) | 0.858, 1.30 |
| Effect of gender on V3/F | 0.891 (17.6) | 0.600, 1.21 | 0.927 (17.2) | 0.612, 1.26 |
| IIV-CL/F | 0.279 (22.4) | 0.165, 0.412 | 0.278 (22.5) | 0.160, 0.407 |
| IIV-V2/F | 0.830 (21.1) | 0.499, 1.19 | 0.827 (22.6) | 0.498, 1.22 |
| IIV-CLM/F | 0.248 (25.7) | 0.147, 0.408 | 0.258 (25.8) | 0.154, 0.428 |
| IIV-V3/F | 0.414 (29.7) | 0.192, 0.643 | 0.424 (29.3) | 0.201, 0.642 |
| IIV-ka | 0.987 (50.8) | 0.548, 2.55 | 0.975 (50.0) | 0.547, 2.46 |
| Residual variability (σ2) for AS | 0.586 (29.2) | 0.510, 1.19 | 0.583 (29.5) | 0.509, 1.19 |
| Residual variability (σ2) for DHA | 0.876 (15.5) | 0.575, 1.13 | 0.872 (15.6) | 0.574, 1.13 |
a
CL/F, V2/F, and ka are artesunate apparent clearance, apparent volume of distribution, and absorption rate constant, respectively. CLM/F and V3/F are DHA apparent clearance and apparent volume of distribution, respectively. CI, confidence interval.