Fig 4.

(A) IC₅₀ curves for inhibitor concentration versus percent Schistosoma mansoni FPPS inhibition. (B) IC₅₀ curves for inhibitor concentration versus percent S. mansoni GGPPS inhibition. (C) Survival of ex vivo adult S. mansoni worms cultured in the presence of 50 μM bisphosphonates 2, 91, and 715 as a function of time. (D) Survival of ex vivo adult S. mansoni worms cultured with 50 μM 2, 91, and 715 and with various concentrations of compounds 746, 766, 777, and 820. Worms were cultured in RPMI medium with inhibitors, with the medium and inhibitors replaced daily. Worms were observed for survival (as assessed by motility) over 6 days. The LD₅₀s of the compounds for adult worms are ∼25 μM.