Table 1.
Summary characteristics of the genes assessed in this study
| PlasmoDB ID | Gene | Chromosome | Annotated product description | No. of TM domains | Repeat position(s) | PfLCR family |
|---|---|---|---|---|---|---|
| PF3D7_0523000 | pfmdr1 | 5 | Multidrug resistance protein 1 | 12 | 643–661 | Poly-Asn |
| PF3D7_1229100 | pfmrp2 | 12 | ABC transporter (CT family) | 12 | 952–998 and 1160–1200 | High GC |
| PF3D7_1339900 | pfmdr5 | 13 | ABC transporter (MDR family) | 5 | 508–551 | High GC |
| PF3D7_1352100 | pfmdr6 | 13 | ABC transporter (heavy metal transporter family) | 12 | 103–109 | Poly-Asn |
| PF3D7_0502400 | pfmsp8 | 5 | Merozoite surface protein 8 | 0 | 164–180 and 189–195 | High GC |
The Plasmodium falciparum low-complexity region (PfLCR) family annotations assigned to various loci were adopted from the clusters described in reference 30, while the number of transmembrane (TM) domains is as predicted by the TMHMM2 algorithm. PfMSP8 is GPI anchored in the membrane and hence lacks transmembrane domains. The amino acid positions of the repeats are indicated relative to the 3D7 reference sequence from PlasmoDB (www.plasmodb.org).