Table 3.
P. falciparum strains sampled and corresponding genotypes of the repeat regionsa
| Origin | Strain | Repeat region profile forb: |
|||||
|---|---|---|---|---|---|---|---|
| pfmdr1 (N-D-N) | pfmdr5 (DNNN-DHHNDHNNDNNN) | pfmdr6 (N repeats) |
pfmrp2 |
pfmsp8 (NDD-DDNDDNG) | |||
| DNNNTS | DNNN | ||||||
| Africac | |||||||
| Netherlands | 3D7 | 7-2-10 | 8-1 | 6 | 8 | 9 | 5-1 |
| Ghana | RO33 | 8-2-09 | 8-1 | ND | 7 | 7 | 2-2 |
| Sierra Leone | D6 | 7-2-09 | 7-1 | ND | 7 | 8 | 5-1 |
| Nigeria | Wellcome | 7-2-07 | 5-1 | 8 | 7 | 8 | 5-2 |
| Uganda | Palo Alto | 7-0-02 | 5-1 | 6 | 7 | 9 | 5-1 |
| South America | |||||||
| Brazil | 7G8 | 7-2-09 | 7-1 | ND | 4 | 7 | 5-1 |
| Brazil | ITG | 7-2-07 | ND | ND | ND | ND | ND |
| Brazil | IT | ND | 5-1 | 8 | 7 | 8 | ND |
| Asia | |||||||
| Thailand | T9102 | 7-2-11 | 5-1 | 4 | 7 | 6 | 5-0 |
| Thailand | K1 | 7-2-09 | 5-1 | 10 | 7 | 6 | ND |
| Indochina | W2 | 7-2-11 | ND | ND | ND | ND | ND |
| Indochina | Dd2 | 7-2-11 | 5-1 | 6 | 7 | 8 | 5-1 |
| Vietnam | V1S | 7-2-11 | 5-1 | 10 | 7 | 7 | 5-2 |
| Thailand | T996 | 8-2-09 | 7-1 | 6 | 7 | 9 | 5-1 |
| China | FCC2 | 7-2-06 | 5-1 | 8 | 7 | 7 | 5-1 |
| Central America | |||||||
| Honduras | HB3 | 7-2-09 | 3-1 | 9 | 7 | 7 | 6-1 |
Samples were obtained from various parts of the world where malaria is endemic.
The pfmdr1 genotype nomenclature describes the number of asparagine (N) repeats followed by aspartate (D) then a final series of asparagine repeats in an N-D-N order. For pfmdr5, the number of DNNN motifs is indicated followed by the number of DHHNDHNNDNNN units, while the values for pfmdr6 are the numbers of asparagines. The numbers of DNNNTS and DNNN motifs are shown for pfmrp2, while the pfmsp8 value is the number of NDD repeats followed by the number of DDNDDNG motifs. ND refers to loci for which there were no evaluable sequences.
3D7 was cloned from NF54, an Amsterdam case of malaria presumably from an African mosquito, and is therefore grouped with the African strains.