Table 4.

Summary of the genotypes for the 5 genes analyzed among the clinical isolates

Gene (motif)	Genotypea	nb	Frequency (%)	Pc
				Chloroquine	Mefloquine	Halofantrine	Lumefantrine	Piperaquine	Quinine	Dihydroartemisinin
pfmdr1 (N-D-N)	7-0-01	19	29.2	0.3058	0.2217	0/7552	0.1706	0.3339	0.8615	0.9540
	7-2-09	7	10.8	0.1330	0.9040	0.2702	0.6568	0.2042	0.0287	0.6415
	7-2-10	22	33.9	0.3749	0.3559	0.1658	0.1078	0.8137	0.4667	0.0369
	7-2-11	8	12.3	0.0052	0.0065	0.1157	0.0360	0.8574	0.0011	0.0052
	7-0-02	1	1.5
	7-0-04	1	1.5
	7-2-06	2	3.1
	7-2-07	4	6.2
	7-3-09	1	1.5
	Total	65	100
pfmdr5 (DNNN-DHHNDHNNDNNN)	5-1	19	32.8	0.8019	0.5080	0.7359	0.0173	0.8694	0.2763	0.8762
	6-1	6	10.3	0.8518	0.3590	0.9392	0.1723	0.9199	0.9328	0.7195
	7-1	15	25.9	0.1739	0.4883	0.3919	0.9631	0.1570	0.8075	0.6772
	8-1	10	17.2	0.3662	0.5330	0.8651	0.0838	0.6635	0.6381	0.8148
	4-1	1	1.7
	4-2	1	1.7
	5-2	2	3.5
	9-1	4	6.9
	Total	58	100
pfmdr6 (N repeats)	6	29	52.7	0.2755	0.5680	0.5540	0.0085	0.0463	0.8761	0.9869
	8	17	30.4	0.8237	0.5797	0.9647	0.0363	0.0036	0.9399	0.7824
	10	2	3.6
	4	1	1.8
	7	3	5.4
	9	4	7.1
	Total	56	100
pfmrp2 (DNNNTS)	10	7	13	0.5726	0.2562	0.6148	0.0781	0.1780	0.3112	0.8629
	7	23	38.3	0.6212	0.6697	0.2371	0.0080	0.8612	0.6362	0.2976
	8	17	28.3	0.7366	0.3661	0.5463	0.4262	0.7740	0.0754	0.6226
	9	9	15	0.5691	0.8343	0.7653	0.8930	0.1886	0.9128	0.4314
	4	1	1.7
	5	1	1.7
	6	2	3.3
	Total	56	100
pfmrp2 (DNNN)	7	20	43.5	0.7733	0.4720	0.9103	0.1436	0.9823	0.6522	0.6576
	8	13	28.3	0.1607	0.0233	0.7431	0.1273	0.2998	0.1511	0.5023
	9	9	19.6	0.8294	0.3601	0.3727	0.8294	0.8294	0.7024	0.5180
	10	2	4.4
	11	1	2.2
	6	1	2.2
	Total	46	100
pfmsp8 (NDD)	6	50	86.2	0.1554	0.5536	0.2191	0.6040	0.4706	0.1144	0.9910
	3	3	5.2
	5	1	1.7
	7	2	3.5
	9	2	3.5
	Total	58	100
pfmsp8 (DDNDDNG)	1	53	91.4	0.2282	0.1166	0.4968	0.7711	0.9669	0.5264	0.8571
	2	5	8.6
	Total	58	100

^aUnderlining indicates profiles with >10% allele frequencies.

^bNumber of samples bearing each genotype.

^cWe used Mann-Whitney's test to compare IC₅₀s for parasites bearing these genotypes versus those that do not, and significant results (P < 0.05) are in bold. This analysis was only done for genotypes with allele frequencies of >10%.