Fig 3.

Telaprevir EC₅₀ fold change and in vitro replicative fitness of NS3 variants in G1b replicon cells. The fold change in mean EC₅₀ and the SD were derived from Table 1 and plotted in the black bars corresponding to the y axis on the left. The replicative fitness (replication capacity) and the SD were derived from Table 5 and plotted in the gray bars corresponding to the y axis on the right. The upper dashed line represents the maximum change in EC₅₀ (i.e., 93-fold) that could be detected in the 96-h EC₅₀ assay. The lower dashed line represents the maximum change in EC₅₀ (i.e., 62-fold) that could be detected in the 48-h EC₅₀ assay. The fold changes in EC₅₀ above the maximum detection limits are represented with the “>” sign.