Table 5.
Dose-scheduling study results for thioridazinea
Parameter | Value for therapy with duration of: |
||||
---|---|---|---|---|---|
7 days | 10 days | 14 days | 21 days | 28 days | |
Cmax/MIC | 0.88 | 0.86 | 0.79 | 0.52 | 0.72 |
AUC/MIC | 0.47 | 0.46 | 0.50 | 0.83 | 0.88 |
%TMIC | 0.14 | 0.21 | 0.17 | 0.47 | 0.78 |
Values in boldface indicate PDI linked to microbial kill.