Table 2.
Antibacterial activities of TXY436 and PC190723 against MSSA and MRSAa
| Strain | MIC (μg/ml) |
|||
|---|---|---|---|---|
| TXY436 | PC190723 | Vancomycin | Oxacillin | |
| 8325-4 (MSSA) | 0.5 | 0.5 | 1.0 | 0.125 |
| ATCC 29213 (MSSA) | 1.0 | 1.0 | 1.0 | 0.25 |
| ATCC 19636 (MSSA) | 0.5 | 0.5 | 1.0 | 0.125 |
| ATCC 49951 (MSSA) | 1.0 | 0.5 | 1.0 | 0.25 |
| ATCC 33591 (MRSA) | 0.5 | 0.5 | 2.0 | >64 |
| ATCC 43300 (MRSA) | 0.5 | 0.5 | 2.0 | >64 |
| Mu3 (MRSA) | 0.5 | 0.5 | 2.0 | >64 |
a
Vancomycin and oxacillin are included as control antistaphylococcal agents. Mu3 is a clinical MRSA isolate also identified as being hetero-GISA (hGISA) (43).