Table 3.
PK-PD parameters in the two hollow-fiber dose-ranging studies for amoxicillin in which a 1.6-h half-life was simulateda
| Treatment arm | Total daily dose (mg) | Target half-life (h) | Free AUC/MIC ratio | Free Cmax/MIC ratio | Free trough/MIC ratio | Free T>MIC (%) | Dose fractionation study result |
|
|---|---|---|---|---|---|---|---|---|
| First study | Second study | |||||||
| ΔSterne control | 0 | NA | 0 | 0 | 0 | 0 | NA | NA |
| Amoxicillin (mg) q8h | ||||||||
| 62.5 | 187 | 1.6 | 38.52 | 3.9 | 0.29 | 69 | Failure | ND |
| 125 | 375 | 1.6 | 77.03 | 7.8 | 0.57 | 85 | Failure | ND |
| 187.5 | 562 | 1.6 | 110.63 | 11.2 | 0.83 | 94 | Failure | ND |
| 250 | 750 | 1.6 | 154.07 | 15.6 | 1.16 | 100 | Failure | ND |
| 500 | 1,500 | 1.6 | 308.14 | 31.2 | 2.32 | 100 | Failure | Failure |
| 875 | 2,625 | 1.6 | 537.27 | 54.4 | 4.04 | 100 | Failure | Success |
| 1,000 | 3,000 | 1.6 | 616.28 | 62.4 | 4.63 | 100 | Failure | Failure |
| 1,250 | 3,750 | 1.6 | 739.49 | 74.9 | 5.57 | 100 | Success. | Success |
a
Amoxicillin was administered to all experimental arms on a q8h schedule. The MIC in broth was 0.25 μg/ml. NA, not applicable; ND, not done.