Fig 3.

(A) Ciprofloxacin concentrations in kidneys of mice (μg/ml), infected with either E. coli CFT073-RR or E. coli CFT073-RR/p449, 15 min (T15) and 60 min (T60) and after injection of 10 mg/kg of ciprofloxacin. (B) Decrease in ciprofloxacin concentrations in kidneys of mice between 15 min and 60 min according to the study strain. The decrease in ciprofloxacin concentrations was significantly more pronounced (P < 0.05) in mice infected with E. coli CFT073-RR/p449 than in those infected with strain E. coli CFT073-RR.