Table 1.
Identification of L. monocytogenes mutants that exhibit low IFN-β response during macrophage infection
| L. monocytogenes 10403S gene | L. monocytogenes EGDe gene identifier | Description | INF-β fold of induction mutant/WT bacteria |
|---|---|---|---|
| LMRG_02622.6 | lmo0200 | PrfA main virulence regulator of L. monocytogenes | 0.159 |
| LMRG_00367.6 | lmo0679 | Flagellar biosynthesis protein FlhB | 0.383 |
| LMRG_00376.6 | lmo0688 | Similar to glycosyl-transferase, group 2 family protein | 0.720 |
| LMRG_00380.6 | lmo0692 | Two-component sensor histidine kinase CheA | 0.486 |
| LMRG_00386.6 | lmo0697 | Similar to flagellar hook protein FlgE | 0.282 |
| LMRG_00395.6 | lmo0706 | Similar to flagellar hook-associated protein 3, FlgL | 0.445 |
| LMRG_0397.6 | lmo0708 | Similar to flagellar biosynthesis protein FliS | 0.561 |
| LMRG_00402.6 | lmo0713 | Flagellar basal-body M-ring protein FliS | 0.594 |
| LMRG_00413.6 | lmo0724 | Similar to B. subtilis YvpB protein | 0.742 |
| LMRG_02270.6 | lmo0847 | Glutamine transporter | 0.493 |
| ∼20bp upstream LMRG_00534.6 | ∼20bp upstream lmo1072 | Highly similar to pyruvate carboxylase | 0.331 |
| LMRG_01443.6 | lmo1527 | Similar to protein-export membrane protein SecDF | 0.354 |
| LMRG_02761.6 | lmo1687 | Hypothetical protein | 0.725 |
| LMRG_02767.6 | lmo1693 | Regulatory protein RecX | 0.830 |
| LMRG_01002.6 | lmo1855 | d-alanyl-d-alanine carboxypeptidase | 0.814 |
| LMRG_01003.6 | lmo1856 | Purine nucleoside phosphorylase | 0.818 |
| LMRG_01264.6 | lmo2110 | Similar to mannose-6 phosphate isomerase | 0.707 |
| LMRG_1717.6 | lmo2531 | ATP synthase F1 alpha subunit | 0.417 |
| LMRG_01981.6 | lmo2715 | ABC transporter CydDC cysteine exporter CydC | 0.840 |
| LMRG_01787.6 and LMRG_01360.6 | lmo2461 and lmo1606 | RNA polymerase sigma-54 factor (sigma-L) and DNA segregation ATPase FtsK/SpoIIIE | 0.506 |