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Effective population of pneumococcus in BALB/c mice. (A) The estimated Ne in BALB/c mice (□) was lower than the CFU recovered on day 8 (■). (B) A range of in vivo generation time was assumed, and the estimated Ne values (left panel) were compared to the CFU recovered on day 8 (right panel). (C) The Ne for different time intervals was estimated by only using the strain frequency data during the time period specified. Error bars represent the 95% CI.
