Fig 3.

Effective population of pneumococcus in BALB/c and DO11.10 RAG^−/− mice. All mice had been exposed to CT 4 to 5 weeks prior to challenge. The point estimate of N_e (□) and mean CFU recovered (■) are shown. The estimated N_e in BALB/c mice (A) or DO11.10 RAG^−/− mice (C) was lower than the terminally recovered CFU. The N_e in different time intervals was calculated by only using the strain frequency data during the time period specified in BALB/c mice (B) and DO11.10 RAG^−/− mice (D). Error bars represent the 95% CI.