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Production of proinflammatory cytokines in sera of OMV-treated mice, as determined by ELISA. WT mouse models were intranasally instilled with 0.5 mg purified OMVs and the same amount of PBS as a control. Sera were harvested at the designated time points. Data are presented as means ± SEM, and data from each column are compared with data from the 0-h time point (*, P < 0.001 [determined by one-way ANOVA followed by a Tukey-Kramer post hoc test]).
