Fig 6.
Role of T cells in vaccine-induced protection against B. pseudomallei. CD8−/− (A), CD4−/− (B), and TCRα/β−/− (C) and WT C57BL/6 mice were immunized twice with Bp82. Naive and immunized animals were then challenged intranasally with 1.2 × 104 CFU of B. pseudomallei 1026b, and survival percentages were determined. Survival percentages for CD8−/−, CD4−/−, and TCRα/β−/− mice compared to WT mice were not significantly different. Survival differences were determined using Kaplan-Meier survival curves and log rank analysis. Data are representative of two independent experiments.