Table 3.
Sensitivities and specificities of VL-RDTs in fresh samples of blood and serum from India and Nepal
| Product | Sensitivity (n [%]) (95% CIa) for sample types from: |
Specificity (n [%]) (95% CI) for sample types from: |
||||||
|---|---|---|---|---|---|---|---|---|
| India |
Nepal |
India |
Nepal |
|||||
| Blood (n = 150) | Serum (n = 150) | Blood (n = 27) | Serum (n = 27) | Blood (n = 119) | Serum (n = 119) | Blood (n = 152) | Serum (n = 152) | |
| Signal-KA | 145 (96.7) (92.4, 98.9) | 149 (99.3) (96.3, 100.0) | 26 (96.3) (81.0, 99.9) | 26 (96.3) (81.0, 99.9) | 115 (96.6) (91.6, 99.1) | 119 (100.0) (97.0, 100.0) | 146 (96.1) (91.6, 98.5) | 146 (96.1) (91.6, 98.5) |
| Crystal-KA | 147 (98.0) (94.3, 99.6) | 149 (99.3) (96.3, 100.0) | 26 (96.3) (81.0, 99.9) | 26 (96.3) (81.0, 99.9) | 119 (100.0) (97.0, 100.0) | 117 (98.3) (94.1, 99.8) | 146 (96.1) (91.6, 98.5) | 146 (96.1) (91.6, 98.5) |
| Onsite Leishmania Ab (RevA) rapid test | 144 (96.0) (91.5, 98.5) | 145 (96.7) (92.4, 98.9) | 27 (100.0) (87.2, 100) | 26 (96.3) (81.0, 99.9) | 116 (97.5) (92.8, 99.5) | 112 (94.1) (88.3, 97.6) | 138 (90.8) (85.1, 94.9) | 137 (90.1) (84.3, 94.4) |
| Onsite Leishmania Ab (RevB) rapid test | 150 (100.0) (97.6, 100.0) | 148 (98.7) (95.3, 99.8) | 27 (100.0) (87.2, 100.0) | 27 (100.0) (87.2, 100.0) | 40 (33.6) (25.2, 42.9) | 50 (42.0) (33.0, 51.4) | 75 (49.3) (41.2, 57.6) | 74 (48.7) (40.5, 56.9) |
| Kala-azar Detect | 149 (99.3) (96.3, 100.0) | 149 (99.3) (96.3, 100.0) | 26 (96.3) (81.0, 99.9) | 26 (96.3) (81.0, 99.9) | 116 (97.5) (92.8, 99.5) | 118 (99.2) (95.4, 100.0) | 143 (94.1) (89.1, 97.3) | 143 (94.1) (89.1, 97.3) |
| DiaMed-IT LEISH | 148 (98.7) (95.3, 99.8) | 148 (98.7) (95.3, 99.8) | 27 (100.0) (87.2, 100) | 26 (96.3) (81.0, 99.9) | 118 (99.2) (95.4, 100.0) | 118 (99.2) (95.4, 100.0) | 142 (93.4) (88.2, 96.8) | 141 (92.8) (87.4, 96.3) |
a
CI, confidence interval.