Table 4.
Quasispecies distribution between W4P/R variants and wild types
| Serum sample (no. of subclones) | RT-PCR detection results | Diagnosisa | No. (%) of samples with: |
Other amino acid substitution (no. of subclones) | |||
|---|---|---|---|---|---|---|---|
| Wild type | W4P | W4R | W4P/R | ||||
| HCC4 (22) | W4P+WT | HCC | 9 | 13 | 0 | 13 (59.1) | |
| HCC5 (21) | W4R+WT | HCC | 7 | 6 | 8 | 14 (66.7) | |
| HCC7 (21) | W4P+WT | HCC | 7 | 11 | 2 | 13 (61.9) | W4Stop (1) |
| LC14 (22) | W4P+WT | LC | 6 | 16 | 0 | 16 (72.7) | |
| LC22 (22) | W4R+WT | LC | 15 | 0 | 6 | 6 (27.3) | W4Q (1) |
| CH31 (16) | WT | CH | 16 | 0 | 0 | 0 | |
| CH32 (16) | WT | CH | 15 | 0 | 0 | 0 | W4Stop (1) |
| C33 (16) | WT | C | 16 | 0 | 0 | 0 | |
| C34 (15) | WT | C | 15 | 0 | 0 | 0 | |
a
HCC, hepatocellular carcinoma; LC, liver cirrhosis; CH, chronic hepatitis; C, carrier.