Figure 4.

MMP-7 expression in neoplastic tissue. (a) Positive signal in the lumens of mammary ducts from a patient with ductal carcinoma in situ. (b) Breast tissue from a non-diseased patient (who underwent reduction mammoplasty) shows no MMP-7 expression in the ducts. (c) Human colonic adenoma shows MMP-7 expression in glandular lumen. (d) Murine intestinal adenoma from a 6-week Apc^Min/+ mouse also shows lumenal staining. (e) Invasive human colonic adenocarcinoma shows MMP-7 is highly expressed in tumor cells, with no apparent discrete cellular localization. (f) Large murine adenoma from a 17-week Apc^Min/+ mouse shows focal expression of MMP-7.