Fig 1.

Increased disease severity and delayed RSV clearance in the lungs of aged mice. Young and aged mice were infected with RSV. (A and B) Disease severity was monitored by weight loss, expressed as a percentage of starting weight (A), and airway resistance (Penh) (B). Data were analyzed by two-way analysis of variance with repeated measures and Bonferroni's posttest. *, P < 0.05; ***, P < 0.001. (C) Viral burdens in the lungs were assessed via plaque assay at days 4, 7, and 12 p.i. Data are cumulative from two separate experiments (n, 8 to 9 mice/group).