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Summary of interaction studies with MLV IN and the BRD2 ET domain
| No. | BRD2 protein | Interaction with MLV INa |
|---|---|---|
| 1 | Wild type | + |
| 2 | E682A/E683A/E685A | + |
| 3 | D687A/E689A | − |
| 4 | R648A/N655A/L662E | − |
| 5 | L676A/S679A | + |
| 6 | R648A/N655A/L676A/S679A | + |
| 7 | L662E | − |
| 8 | N655A | + |
| 9 | R648A | + |
| 10 | D687A | + |
| 11 | E689A | + |
| 12 | F688Y | +/− |
| 13 | S651E | +/− |
| 14 | S651N | +/− |
| 15 | S651K | + |
+, strong; +/−, weak; −, none.
