Table 3.
Neutralization potencies and binding avidities of group-reactive human anti-E MAbs in this study
| MAb | Patient ID, immune statusa | Neutralization potency (FRNT50 value) (μg/ml) |
Kd (μg/ml)b | |||
|---|---|---|---|---|---|---|
| D1 | D2 | D3 | D4 | |||
| DVG1.3 | DVG, primary D1 | 1 | 0.25 | >1 | 1 | 0.021 ± 0.002 |
| DVG6.3 | DVG, primary D1 | >1 | 1 | >1 | >1 | 0.397 ± 0.078 |
| DVG7.5 | DVG, primary D1 | 1 | 1 | >1 | >1 | 0.777 ± 0.048 |
| DVG12.2 | DVG, primary D1 | >1 | >1 | >1 | 1 | 0.684 ± 0.052 |
| DVD19.4 | DVD, primary D4 | >1 | 1 | >1 | 0.25 | 0.199 ± 0.027 |
| DVD19.13 | DVD, primary D4 | 1 | 0.25 | >1 | 1 | 0.296 ± 0.037 |
| DVD23.3 | DVD, primary D4 | 1 | 1 | >1 | 0.25 | 0.207 ± 0.019 |
| DVD23.4 | DVD, primary D4 | >1 | 0.25 | 1 | 1 | 0.234 ± 0.024 |
| DVD26.3 | DVD, primary D4 | >1 | 1 | >1 | 1 | 0.509 ± 0.056 |
| DVD26.11 | DVD, primary D4 | >1 | >1 | >1 | >1 | 1.878 ± 0.178 |
| DVC23.13 | DVC, primary D2 | 1 | 1 | 1 | 1 | 0.065 ± 0.005 |
| DVB64.31 | DVB, primary D3 | 1 | >1 | >1 | >1 | 0.360 ± 0.030 |
| 749B2 | 749, secondary D1 | 1 | 0.25 | 1 | 0.25 | 0.052 ± 0.005 |
| 749B4 | 749, secondary D1 | 0.063 | 0.25 | >1 | 0.016 | 0.043 ± 0.003 |
| 749B6 | 749, secondary D1 | 1 | 1 | >1 | >1 | 0.032 ± 0.002 |
| 749B12 | 749, secondary D1 | 0.063 | 0.25 | 1 | 0.016 | 0.034 ± 0.003 |
| 751A1 | 751, secondary D1 | 0.25 | 0.25 | 0.25 | 0.25 | 0.047 ± 0.003 |
| 751A2 | 751, secondary D1 | 0.25 | 0.25 | 1 | 1 | 0.097 ± 0.005 |
| 751A12 | 751, secondary D1 | 1 | 1 | >1 | 1 | 0.052 ± 0.007 |
| 751B3 | 751, secondary D1 | 1 | 0.25 | 1 | 1 | 0.105 ± 0.009 |
| 751B6 | 751, secondary D1 | 0.063 | 0.063 | 0.83 | 1 | 0.025 ± 0.002 |
| 751B11 | 751, secondary D1 | 0.25 | 0.25 | 1 | 0.25 | 0.013 ± 0.001 |
| 751B12 | 751, secondary D1 | 1 | 0.25 | 1 | 0.25 | 0.022 ± 0.001 |
| 751C4 | 751, secondary D1 | 0.25 | 0.063 | 0.31 | 0.25 | 0.011 ± 0.001 |
| 751C10 | 751, secondary D1 | 0.063 | 0.063 | 1 | 0.063 | 0.019 ± 0.003 |
| 753A1 | 753, secondary D1 | 1 | 0.25 | >1 | 1 | 0.130 ± 0.010 |
| 753C1 | 753, secondary D1 | 0.25 | 0.063 | 0.25 | 0.25 | 0.015 ± 0.001 |
| 753C6 | 753, secondary D1 | 0.063 | 0.063 | 1 | 0.25 | 0.024 ± 0.002 |
| 753C8 | 753, secondary D1 | 1 | 0.25 | 1 | 1 | 0.063 ± 0.004 |
| 753C12 | 753, secondary D1 | 0.25 | 0.063 | 0.25 | 0.063 | 0.035 ± 0.003 |
| 750C9 | 750, secondary D1 | 0.25 | 1 | >1 | 1 | 0.296 ± 0.030 |
| 750D7 | 750, secondary D1 | 1 | 0.25 | >1 | 1 | 0.070 ± 0.006 |