Fig 2.

Reduced contraction of antigen-specific CD8 T cell responses and increased memory precursor cell compartment in IFN-γ^−/− and IFN-γR^−/− mice after influenza virus infection. C57BL/6 WT, IFN-γ^−/−, and IFN-γR^−/− mice were infected with 5 PFU of influenza A/PR/8/34 virus. NP₃₆₆⁺ CD8⁺ T cell numbers were examined in the BAL fluid (A), lung tissue (B), and spleen (C) on day 28 p.i. and in the lung tissue on day 120 p.i. (D). The numbers of CD8⁺ NP₃₆₆⁺ cells (means ± SEM) shown were calculated from the total counts and the percentages of cells staining positive. *, P < 0.05; **, P < 0.01; ***, P < 0.001 (determined using Student's t test). Data are representative of at least 3 independent experiments with 4 or 5 mice per group.