Fig 6.

IFN-γ deficiency does not affect the effector function of antigen-specific CD8 T cells after influenza virus infection. C57BL/6 WT, IFN-γ^−/−, and IFN-γR^−/− mice were infected with 5 PFU of influenza A/PR/8/34 virus, and the percentages of NP₃₆₆⁺ CD8 T cells expressing IL-2 (A) and TNF-α (B) on day 8 p.i. were measured. Cytotoxic profiles are shown for CD8 T cells from the lung on day 7 (C) and day 11 (D) p.i., determined by ⁵¹Cr release assay and expressed as percentages of specific lysis of target cells. Data are representative of at least 3 independent experiments with 4 or 5 mice per group.